Malawi became the first nation to reach the group stages of qualifying for the Africa Cup of Nations with victory over Benin on Saturday.
Trailing 1-0 from the first leg, Young Chimodzi's side restored parity courtesy of an early goal from John Banda at the Kamuzu Stadium in Blantyre.
The sides could not be separated during normal time or extra time, with Malawi ensuring their progress courtesy of a penalty shootout victory.
Having overcome Chad on away goals to reach the second qualifying round, Malawi will now move into Group B of the main qualifying section alongside Mali, Algeria and Ethiopia.
Rwanda, ranked 30th on the continent, came from 2-0 down in the first leg to see off Congo on penalties.
After giving themselves a mountain to climb, courtesy of first-leg goals from Cesaire Gandze and Ferebory Dore, Saturday's hosts levelled the aggregate score shortly after half-time when Michel Ndahinduka and Meddie Kagere struck.
After they levelled the tie, Rwanda came through 4-3 on penalties to complete an impressive comeback and book themselves a place in Group A of qualifying alongside reigning champions Nigeria.
Botswana succesfully defended a two-goal lead against Guinea-Bissau with a 1-1 draw in the second leg at the Estadio 24 de Setembro.
Ivanildo threatened a comeback with a goal after 20 minutes but Jerome Ramatlhakwane calmed any Botswana nerves with a goal in the final minute of normal time to ensure progression.
Sierra Leone and the Seychelles were due to meet in the second leg of their tie with the former leading 2-0.
However, the Seychelles' Football Federation decision to withdraw, reportedly due to health fears over the Ebola virus, ensured their opponents progressed to Group D.