Bordeaux handed Monaco test
League leaders Bordeaux easily went through with a 5-1 demolition of second division Ajaccio on Saturday while Monaco struggled past former champions Olympique Lyon 2-1 on Sunday.
Cup holders Guingamp, who are 17th in Ligue 2, will travel to fourth-division Colmar or Ligue 1 strugglers Boulogne.
Paris Saint-Germain visit fourth division Vesoul after they knocked out fifth division Aubervilliers and third division Evian in previous rounds.
Many ties are still to be determined as only eight games from the round of 32 were played over the weekend.
Bad weather disrupted the fixture schedule this month and many games from the round of 64 were postponed.