The Lisbon club ended the group phase above second-place Basel who shocked Premier League champions Manchester United with a 2-1 win in the final match.
"We must stress this brilliant campaign of ours," Benfica coach Jorge Jesus told reporters. "Benfica's group had three excellent teams and United, who were the favorites, were knocked out, that says it all."
Otelul exit the Champions League without earning a single point in their debut campaign.
Benfica had secured qualification with an impressive 2-2 draw at United in the previous round and allowed themselves to relax and control the tempo of the match after an early Cardozo goal.
Argentine winger Nicolas Gaitan ran to the byline inside Otelul's box and his clever pass found the Paraguayan striker who coolly tapped in the winner in the seventh minute.
SILKY AIMAR
Silky playmaker Pablo Aimar and the clever Axel Witsel pulled the strings in the midfield, giving the visitors little leeway as Benfica controlled possession throughout.
"We are very ambitious we accomplished the objective of being first but the key goal was to get to the last 16 round. Now we will see what the draw has in stall for us and in what form we will be in the knockout," Aimar said.
Cardozo, Benfica's top goalscorer in the competition with three goals, almost grabbed a second in the 33rd minute with a shot from outside the box that went inches wide.
Moments later, in a rare chance for the Romanians, forward Gabriel Paraschiv caught Benfica's defence napping but lost out in the one-on-one duel with Benfica keeper Artur, who also saved Gabriel Giurgiu's rebound shot.
Benfica kept control in the second half and Otelul took no risks. Cardozo headed over keeper Branko Grahovac's goal, Javi Garcia went close with a cracking shot from distance and substitute Rodrigo also missed two good chances.
"It was important to finish first because it allows us to escape from meeting a few big sharks in the next round," Benfica's Ruben Amorim said.
