Ronaldo out of Sevilla showdown
The Portuguese forward was injured when Olympique Marseille defender Souleymane Diawara fouled him and conceded a penalty in the second half of Real's 3-0 Champions League win on Wednesday.
Coach Manuel Pellegrini has not included Ronaldo in his squad for the match against the Andalusians, the club said on their website, as Real seek a sixth win out of six this season.
Striker Ruud van Nistelrooy, midfielders Lassana Diarra and Fernando Gago and defender Alvaro Arbeloa are also unavailable because of injury, the club added.
Real top La Liga on goal difference from Barcelona, who also have 15 points, and Sevilla are third on 12.