Phil Brown's Tigers face the already-crowned Premier League champions knowing a victory will ensure their top-flight survival and send the Magpies down to the Championship.
While a draw or defeat for City will hand Newcastle the opportunity to usurp them if they can avoid defeat at Aston Villa.
However, with the Red Devils due to face Barcelona in the Champions League final in Rome just three days later, Ferguson is expected to rest a host of his star names in preparation for next Wednesday's hugely-anticipated clash.
But Shearer has shrugged off suggestions that his side's hopes of avoiding the drop will be disadvantaged by United's team selection at Hull, insisting the champions will be going all out for a victory on the final day of the campaign, no matter which players are picked.
"Alex, when he has been in that position, has always put out a side that does his club proud," he said.
"So whoever he puts out, Manchester United are that professional so they will go out and try to win that game.
"I have not got any problems with that."
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