Holders Al Ahly will need to come from behind if they are to qualify for the group stage of the CAF Champions League.
The Egyptian outfit suffered a 1-0 defeat in the first leg of their last-16 clash with Al Ahli Benghazi of Libya last week, Edward Sadomba scoring the only goal of the encounter in the 67th minute.
Al Ahly - the record eight-time winners of the competition - therefore need to show character if they are to avoid a premature exit this time around.
Compatriots Zamalek should have confidence heading into the second leg of their tie with Nkana, after claiming a goalless draw in Zambia on Saturday.
TP Mazembe, who are four-time winners of Africa's premier club competition, were on the receiving end of a 2-1 defeat at Sewe Sport of the Ivory Coast last time out.
However, Mbwana Samatta's 89th-minute away goal could prove an important factor in the tie.
1973 champions AS Vita pulled off the most impressive result of the first -leg fixtures, triumphing 3-0 over Kaizer Chiefs.
Although the South Africans dominated much of the encounter, Ndombe Mubele put Chiefs to the sword with a hat-trick, giving the men from the Democratic Republic of Congo a comfortable cushion as they head to Johannesburg.
Sfaxien - current holders of the CAF Confederation Cup - have made a big impact in this season's Champions League and possess a 100 per cent record in the competition so far.
The Tunisians host Horoya of Guinea this weekend and take a 1-0 lead into the clash.
Esperance de Tunis have the advantage of an away goal as they welcome Real Bamako on the back of a 1-1 draw first time around, while CotonSport of Cameroon will need to come from a goal down against Entente Setif if they are to progress to the group stage.
In the round's remaining tie, AC Leopard's and Al Hilal share a 1-1 draw heading into the second leg.