Which Premier League clubs will be hit hardest by the Africa Cup of Nations?
3. West Ham
West Ham could also lose a trio of players: Sofiane Feghouli, who's admittedly made little impact at the London Stadium; Cheikhou Kouyate, a much more important figure for the Hammers; and Andre Ayew, who has struggled to make an impact because of injury following his £20m switch from Swansea.
Mame Biram Diouf has made 12 league appearances in 2016/17 and will be tough for Mark Hughes to replace when he swaps Stoke's shirt for Senegal's in January, while Egyptian winger Ramadan Sobhi has shown plenty of promise in recent weeks.
Although Wilfried Bony has disappointed since joining the Potters on loan from Manchester City, the Ivory Coast striker has a proven track record in the Premier League and represents a fantastic option from the substitutes' bench. He could be in Gabon for some time, with the Ivorians among the favourites to take the title.
Leicester, though, will lose out most. Jeff Schlupp and Daniel Amartey will both be turning out for Ghana, while star man Riyad Mahrez and Islam Slimani will be shooting for silverware with Algeria.
The latter pair will be particularly missed by Claudio Ranieri, with Mahrez and Slimani having been directly involved in 52 per cent of the 23 goals the Foxes have scored in the Premier League this term. Leicester fans will be praying for an early exit for the Fennecs.