Marcelo Vieira da Silva Júnior
Gareth Bale is back in the Real Madrid squad as they look for a first win in four in all competitions at Deportivo Alaves on Saturday.
Real Madrid have not won any of their last three matches, and Julen Lopetegui feels injuries have played their part.
The Brazilian FA has confirmed Real Madrid left-back Marcelo will not be available for games against Saudi Arabia and Argentina.
Real Madrid have been weakened by the losses of Gareth Bale and Sergio Ramos ahead of their second Group G match in the Champions League.
Thibaut Courtois will face his old side Atletico Madrid for the first time since joining Real Madrid, but Marcelo is ruled out.
Saturday's LaLiga derby between Real Madrid and Atletico Madrid will likely be played without Marcelo and Gelson Martins.
With Saturday's derby against Atletico Madrid looming, there are question marks over Marcelo's fitness.
Tite has included three uncapped players in his latest Brazil squad including Barcelona's Malcom.
Cristiano Ronaldo is not the only player missed at the Santiago Bernabeu after Saturday's 1-1 draw against Athletic Bilbao, said Marcelo.
Real Madrid defender Marcelo has agreed to a hefty fine to settle a tax fraud case, it has been reported.