Cupsetters Swansea to meet Fulham in fifth round
The Championship side were deserved 2-0 winners at Fratton Park on Saturday and will fancy their chances of another upset on home soil.
Manchester United, Cup winners a record 11 times, travel to either Derby County or Nottingham Forest of the Championship, while Chelsea are also away, at Watford.
The only definite all-Premier League clash is at Upton Park where West Ham United face Middlesbrough.
Liverpool or Everton, who drew 1-1 at Anfield on Sunday, will be at home to Doncaster Rovers or Aston Villa.
Last year's runners up Cardiff City or 10-times winners Arsenal, goalless in Wales on Sunday, will face West Bromwich Albion or Burnley.
The games will be played over the weekend of February 13/14/15.