Favre fired by Hertha Berlin
Sunday's reverse was their sixth league defeat in a row and followed a 4-0 loss at home to promoted Freiburg the week before.
They were also knocked out of the German Cup by second division 1860 Munich in midweek.
"Hertha BSC....have released the coaching team of Lucien Favre and Harald Gamperle from their jobs with immediate effect," the club said on their website.
Hertha said under-23 coach Karsten Heine would take over on an interim basis.
Swiss Favre was the fourth Bundesliga coach to lose his job since the season started in August.
Promoted Mainz 05 fired Joern Anderson after a first-round cup exit to fourth-division VfB Luebeck and before they had played a league game.
Dieter Hecking parted company with Hanvoer 96 in mid-August and Favre's compatriot Marcel Koller was sacked by VfL Bochum last week.
Hertha, who have three points from seven games, appear to be suffering a hangover from last season when they were title contenders with only a few matches remaining, only to finish outside the Champions League places following a late slump.