Leaders PSV defeat Den Haag
Mexican Francisco Rodriguez opened the scoring after 16 minutes when he nodded in a corner from Balazs Dzsudzsak at the near post and Ola Toivonen netted a rebound after the break to make sure of victory.
Fifth-placed Heracles Almelo fought back from two goals down to beat nine-man Groningen 4-3.
Groningen went 3-1 up thanks to two goals from Thomas Enevoldsen and one by Morten Nordstrand but red cards for Gibril Sankoh and Leandro Bacuna early in the second half gave Heracles hope.
Bas Dost grabbed his second goal of the match for the home team in the 72nd minute before Willy Overtoom levelled and Birger Maertens scored the winner with a minute left.
Elsewhere, Heerenveen beat Utrecht 2-0 and Roda JC Kerkrade overcame Sparta Rotterdam 2-1.