Lyon face fourth-tier neighbours in French Cup
Stade Rennes host struggling Nancy in the other game featuring two top-flight teams.
The ties will be played on January 7-8 with big spending Paris Saint-Germain, second in the league behind Montpellier on goal difference, travelling to fifth division Locmine Saint-Colomban.
Montpellier face an even easier task on paper after they were drawn at sixth division Prix les Mezieres.
Seven-times French champions Olympique Lyon were drawn away against neighbours Lyon La Duchere who play in the fourth division.