PSV held by Vitesse Arnhem
PSV stay top on goal difference from Twente. Both have 52 points after 20 matches. Third-placed Ajax have 43 points after a 1-1 draw away at fierce rivals Feyenoord who are fourth on 39 points.
Kenneth Perez broke the deadlock for Twente in the 71st minute and Costa Rican Bryan Ruiz sealed victory a minute later with his 14th of the season.
Ajax went ahead against Feyenoord through Marko Pantelic after 25 minutes after good work from Demy de Zeeuw and Dennis Rommedahl.
Georginio Wijnaldum earned a deserved point for the home side midway through the second half after a defensive blunder from Urby Emanuelson.