PSV see off Sparta to go top
They have 39 points, one more than Twente Enschede who travel to Willem II Tilburg on Saturday.
Ajax Amsterdam, third with 32 points, are at Vitesse Arnhem on Sunday, while ADO Den Haag host fourth-placed Feyenoord.
Serbian Danko Lazovic put PSV ahead with a close-range header after 13 minutes but Rydell Poepon equalised for Sparta before the break, netting a fine pass from Darko Bodul.
Poepon scored his second early in the second half to put Sparta ahead but Jonathan Reis and Balazs Dzsudzsak both scored within four minutes to turn the tide in favour of PSV.