United set record of 21 games unbeaten
United, who won their last-16 tie 2-0 on aggregate, broke the record they shared with Juventus, who went 20 matches unbeaten in the Fairs Cup/UEFA Cup between 1970 and 1972.
The English champions' last defeat in Europe was 3-0 away to AC Milan in the semi-finals of the 2007 Champions League.
United also extended their unbeaten home record in the Champions League to 19 matches, winning 15 of them. AC Milan were the last team to beat United at Old Trafford in the competition, 1-0 in the same round four years ago.