Chile games postponed due to quake
Two coaches lost their jobs in Uruguay, Ecuadorean champions Deportivo Quito lost again and Olimpia ended Cerro Porteno's 100 percent run in Paraguay.
Two coaches lost their jobs as former Uruguay midfielder Mario Saralegui was sacked by Central Espanol and Danubio's Jorge Giordano was also dismissed, taking the total this year to four.
Saralegui had only been in charge since mid-December, appointed after the team's poor Apertura championship, but they have taken a mere five points from six matches in the Clausura.
Danubio's summer recruiting, which included former Inter Milan and Uruguay forward Alvaro Recoba, has not paid dividends.
With seven points Danubio are 11 behind leaders Penarol who have a maximum 18 after a 3-2 win over River Plate.
Penarol went two up in the opening seven minutes with goals from teenage midfielder Jonathan Matias Urretaviscaya da Luz and defender Gerardo Alcoba.
Penarol defender Matias Aguirregaray was sent off in the 54th minute and River fought back with a penalty by Jorge Zambrana three minutes later and a strike by substitute John Varela in the 74th but Urretaviscaya hit the winner four minutes later.
Champions Nacional, who beat Racing 3-0, are eight points behind arch-rivals Penarol.
Champions Deportivo Quito went down to their third defeat in four matches, 3-0 at Manta after a suspension for unpaid debts was lifted in time for the match to go ahead.
Deportivo had been warned they would not be able to play and would lose the points if the debts they had with the Ecuadorean Football Federation were not settled by Friday - which they were.
Their Argentine forward Franco Niell was sent off in the 74th minute.
Barcelona, who won 1-0 at home against Olmedo, share the lead with LDU Quito and Deportivo Cuenca on 10 points after four matches. Manta are three points behind.
LDU crushed Barcelona's Guayaquil neighbours and arch-rivals Emelec 5-0 with two goals from Uruguayan forward Juan Manuel Salgueiro.
Salgueiro has joined LDU on loan from Estudiantes of Argentina to fill the void left by Argentine Claudio Bieler who returned home to play for Racing Club.
Former Ecuador striker Ivan Kaviedes scored a hat-trick as Macara beat promoted Universidad Catolica 3-2.
Paraguay forward Nelson Cuevas scored the winner as Olimpia ended Cerro Porteno's 100 percent record with a 3-2 victory in an exciting Asuncion derby in which both teams played all out for victory at the national Defensores del Chaco stadium.
Cerro still lead the Apertura championship with 15 points from six matches.
Second-placed Guarani are one point behind after a 1-1 draw with 3 de Febrero, while Olimpia climbed to third with 11 points.