Toronto travel to Philadelphia Union on Saturday looking to build on last week's drought-ending win.
Vancouver Whitecaps held on for a 4-3 win over Toronto FC, while Colorado Rapids had to settle for a 1-1 draw with Columbus Crew.
Andy Carroll West Ham looked a tired outfit lacking sharpness as they went down to Seattle Sounders in their pre-season opener in Seattle on Tuesday.
Bradley Wright-Phillips New York Red Bulls dismantled Montreal Impact 4-0, while LA Galaxy and Seattle Sounders shared the spoils in Sigi Schmid's first game.
Houston Dynamo The Houston Dynamo have a tough ask to preserve their perfect MLS record, with a trip to Vancouver Whitecaps on Saturday.
Josef Martinez and Miguel Almiron helped Atlanta United come from behind to beat the San Jose Earthquakes.
DaMarcus Beasley Goals from Will Bruin and Cristian Roldan, and Victor Rodriguez's late double put Seattle on the verge of the play-offs.
Vancouver Whitecaps and Sporting Kansas City reeled in Seattle Sounders on Saturday with streak-ending wins in the MLS.
Toronto Thierry Henry and Tim Cahill could return for the New York Red Bulls in time for their clash with the Philadelphia Union on Saturday.
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