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Emre Can has returned to Juventus training after recovering from surgery on a thyroid nodule.
Can required an operation to solve the problem after his diagnosis, but after a month out he is closing in on a return to action.
Pjanic sustained an injury while on international duty with Bosnia-Herzegovina, while Khedira sprained an ankle in training.
Both midfielders are doubtful for Saturday's game at home to SPAL, with Juventus seeking to extend their best ever start to a Serie A season.
