Olivier Giroud will miss Wednesday's EFL Cup quarter-final against Southampton due to a groin injury, but Lucas Perez is ready to make his comeback from an ankle problem.
France international Giroud was expected to start after having to settle for a spot on the bench behind Alexis Sanchez in recent weeks.
Giroud's absence could see Arsene Wenger give Perez the nod, with the Arsenal boss planning to field a mixture of first-team players and youngsters.
"Lucas is in the squad," Wenger was quoted as saying on the club's official website.
"We will have a mixture of youth and experience, but still 90 per cent of the first-team squad."
Who's likely to be in the squad for ?We asked the boss...November 29, 2016
Mathieu Debuchy, meanwhile, is also unavailabe due to a hamstring problem, with the wing-back to undergo a scan on Tuesday.
"Mathieu has a scan Tuesday, but we do not have the results yet," Wenger added.
Get the best features, fun and footballing frolics straight to your inbox every week.
Thank you for signing up to Four Four Two. You will receive a verification email shortly.
There was a problem. Please refresh the page and try again.