Lille hold the advantage in the race for the third and final UEFA Champions League spot, but are being closely pursued by several teams all looking to seal a place in Europe's premier club competition.
Lyon are among the sides in the hunt and sit five points adrift of Lille in sixth after suffering two defeats in 14 league matches.
However, recent history ahead of this weekend's meeting favours Lille, who have lost only twice at the Stade Pierre Mauroy in the league all season and have not suffered a home defeat to Lyon since 2008.
Claudio Ranieri's men know a win on Friday will move them within two points of leaders and defending champions PSG, the visitors to Toulouse two days later.
Local bragging rights will be at stake at the Stade de la Beaujoire as Nantes look to complete a Breton derby double over arch-rivals Rennes, while third-bottom Valenciennes host Sochaux, the team immediately below them, in a crucial relegation clash.
Elsewhere, Evian take on Bordeaux in a game between last year's Coupe de France finalists, rock-bottom Ajaccio visit Montpellier and Guingamp face Nice.
