They will need some help, however, from the United States to avoid the play-off route and pip Costa Rica to third place.
The United States and Mexico have secured two of the three automatic spots for the 2010 finals in South Africa, while Costa Rica's 4-0 win over bottom team Trinidad and Tobago has pushed them into third place.
'SOCIAL RESPONSIBILITY'
"We all want to go to the World Cup. We've got a social and professional responsibility with the fans," Honduras coach Reinaldo Rueda told a news conference in El Salvador.
"I imagine it is going to be a tense game, just like it was in San Pedro Sula ... El Salvador want to finish well for their fans and for the great job they have done."
Rueda will have to decide whether to start with David Suazo in attack or stick with Saturday's pairing of Carlos Costly and Carlos Pavon.
"We are professionals and we are going to take the game very seriously and responsibly. We want to finish well," said El Salvador's Mexican coach Carlos de los Cobos.
"We have a chance to qualify directly and we must try to seize it," said Costa Rica's Brazilian coach Rene Simoes.
"We are not thinking about play-offs or Argentina or things down the road that we can't control. We are just thinking about winning our game."
