Neymar, who was suspended for the domestic match had played for a Santos reserve team in their friendly against Major League Soccer's NY Red Bulls in New Jersey on Saturday, while Robinho watched from the stands with a minor thigh problem.
Ituano, whose president and captain is former Middlesbrough, Atletico Madrid and Brazil midfielder Juninho, stung Santos by taking the lead through Joao Leonardo after two minutes.
Santos equalised through Andre 12 minutes later and after Ituano's Carlos Eduardo was sent off for a second yellow card offence, a tackle from behind on Paulo Henrique, in the 26th minute the floodgates opened.
"Even with two leading absentees, the team were extremely efficient, coming from behind in the score and playing a strong game," coach Dorival Junior said.
In the Carioca (Rio de Janeiro) championship, Adriano salvaged a 2-2 draw for Brazilian champions Flamengo in the derby against Botafogo with both his team's goals, the second an injury-time header for the equaliser.
Gremio's arch-rivals Internacional were held 2-2 by Pelotas to go four games without winning, including two Libertadores Cup matches.
