Colombia: Three sent off in Medellin mauling
Penarol, one of Uruguay's "Big Two" clubs, extended their record start to the Clausura with a tenth consecutive victory.
Real Cartagena's unbeaten run came to an end after 10 matches in the Apertura when they lost 3-0 at Deportivo Pereira.
Their lead was cut to three points by champions Independiente Medellin, who crushed eight-man Envigado 7-1 with hat-tricks from Paraguayan Mario Gimenez, who scored his three goals in the space of 18 minutes, and Luis Arias.
Former Colombia international Gerardo Bedoya and Neider Morantes were sent off just past the hour and their fellow midfielder Dorlan Pabon in the 76th as Envigado's frustration boiled over.
Millonarios ended a run of 10 Bogota derbies against Independiente Santa Fe with a 2-1 win, a week after the resignation of coach Luis Augusto Garcia due to poor results.
A last-minute own goal by Defensor Sporting midfielder Pablo Gaglianone at a corner gave Penarol a 3-2 win to increase their record start to the Clausura to a 10th consecutive victory and open a 10-point lead.
Gaglianone gave Defensor the lead in the 42nd-minute when he netted the rebound after his penalty was saved. Penarol striker Antonio Pacheco equalised from the spot in the 58th.
Forward Ignacio Risso put Defensor ahead again in the 73rd only for midfielder Gaston Ramirez to head an equaliser with 10 minutes remaining.
Fenix remain in second place by one point from champions Nacional and Cerro after being held 1-1 at Tacuarembo.
Cerro, who are enjoying a good run in the Libertadores Cup, beat Nacional 3-1 to join them in third place.
Union Espanola's Ecuadorean defender Giovanny Espinoza accused Nublense's Argentine defender Matias Manrique of racist insults after his team's 3-1 defeat. The incident is being investigated and Manrique faces a possible sanction.
Universidad de Chile, who recovered from a two-goal deficit to beat Union San Felipe 4-2, lead the standings with 19 points.
Colo Colo climbed to second on 16 points with a 2-0 win over lowly San Luis in the port city of Valparaiso with two goals from Chile striker Esteban Paredes.
San Martin and Cesar Vallejo continue to lead the championship by two points from Sporting Cristal after wins at the weekend.
Sporting recovered from their humiliating 4-0 rout at home by San Martin last weekend with a 2-1 win away to Sports Boys, their Uruguayan striker Miguel Ximenez heading the 88th-minute winner.
Alianza Lima, whose form has been erratic since their brilliant 4-1 rout of South American champions Estudiantes de La Plata in the Libertadores Cup six weeks ago, lost 4-2 to Melgar in the southern city of Arequipa and are nine points off the pace.