The Croatian is beginning his third term with the North London side since joining from Dinamo Zagreb in 2007, but has spent the majority of his Arsenal career on the sidelines through injury.
The 26-year-old was just establishing himself as a Gunner when he suffered a horrific broken leg and dislocated ankle in a tackle with Birmingham City's Martin Taylor in February 2008 that threatened to end his career.
And having sustained several more minor injuries that have hampered his comeback, Eduardo is now ready to re-launch his career at the Emirates Stadium, scoring his first of the campaign in the 6-1 demolition of Everton.
And Wenger believes that the striker - who is effectively a new signing for the Frenchman - can have an extremely successful season if he stays fit.
"Eduardo was one of the players we missed terribly because he can score goals and provide," he said.
"It is a massive season for Eduardo because he was out for such a long time - he was out before he could prove what a big player he is.
"In the first season for the first six months, he did not play a lot. When he then came in and showed his class, he was then injured and lost a whole season.
"Now he is in the third season, without having the opportunity until now to prove how good he is."
Eduardo is expected to play in the Champions League clash with Celtic on Wednesday evening ahead of Robin van Persie, who will be rested ahead of the weekend's meeting with Manchester United at Old Trafford.
And Wenger added that he is delighted to have the Croatian international available for selection once more after not knowing if he would ever play again.
"I had doubts about his injuries and only fools would say they had no doubt," he said.
"When you see his first injury, you had to have doubts, but he has shown his strength of character - and now I have no doubts any more about him because for me he is completely a normal player."
