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La Liga outfit Espanyol announced on Saturday that they had agreed to sell the 24-year-old to the Serie A side, and the deal has now been ratified.
The agreement is believed to be worth around €5 million and sees Lopez become Napoli's fifth acquisition of the transfer window.
Lopez told Napoli’s official website: "I'm happy to be at Napoli, an important club with a wonderful audience."
A product of Espanyol's academy system, Lopez made 41 appearances in all competitions for the Catalan club, scoring three goals.
