United go into the game at the Etihad Stadium three points ahead of their neighbours at the top of the table with three matches left in the season.
"We know the exact situation we're in. We're in a better position than Manchester City," Ferguson told a news conference.
"We could come out with two good results whereas they only have one. Although you know my attitude and this club's attitude - we'll be trying to win."
"I think there's enough experience. Patrice Evra, Rio Ferdinand, even Wayne Rooney has amassed a lot of football in his short time in the game," he said.
"Michael Carrick as well. There's enough experience in the camp to cope with this situation."
"I think the previous encounters this season are irrelevant," Ferguson said.
"We've already met three times but the past is the past," added Ferguson referring to United's victory in the pre-season Community Shield match. "It doesn't matter. It's all down to Monday."
"I suppose when the fixture came out at the beginning of the season all the roads pointed to this game," Ferguson said.
"It was inevitable maybe. But we are where we are and it doesn't matter what's happened before, who's dropped points or who hasn't dropped points. It really is all down to this game.
"It will be a fantastic atmosphere and I hope it lives up to the billing."
"We're smarting from throwing that game away last week," he added.
"In the context of our history we almost expected it. We tend to make it hard for ourselves. Our supporters have been subjected to that sort of drama for years and years.
"God knows what their nerves are like now but, hopefully, we'll make amends on Monday," said Ferguson.
