America, who were unable to celebrate their October 12 birthday the previous weekend because of Mexico's World Cup qualifier, have gone 13 years without being able to mark the event with a victory.
They are third in Group Two three points behind leaders Morelia and one behind Monterrey with their clash against arch-rivals Guadalajara, the biggest match in Mexico, coming up next weekend.
Group One is led by Toluca, who were held 1-1 at home by Tigres UANL.
Toluca are nine points clear of second placed San Luis, who got their first win under new Argentine coach Miguel Angel Lopez beating title holders Pumas UNAM 1-0, their eighth defeat in 12 matches.
Argentine midfielder Eduardo Coudet crossed from the right for Braulio Luna to head the winner in the 65th minute.
Cruz Azul, who beat Estudiantes 3-1, and Santos Laguna are neck and neck on 21 points at the top of Group Three. But Santos can go out in front when they meet Guadalajara on Monday.
Argentine striker Emanuel Villa scored Cruz Azul's third goal to take his tally to 11 as the championship's leading scorer.
The top two teams in each group and the two highest teams in the overall standings go through to the championship phase. There are five matches remaining in the qualifying phase.
