The Copa Libertadores quarter-finals beckon for Palmeiras after Miguel Borja's two-goal haul downed Cerro Porteno 2-0 in the opening leg of their last-16 tie.
Colombia international Borja scored a second-half brace away from home in Asuncion to put Palmeiras in a strong position on Thursday.
With former Brazil boss Luiz Felipe Scolari – who oversaw the club's only Copa Libertadores title in 1999 – back at the helm for a third spell as head coach, Palmeiras drew first blood against the Paraguayan hosts.
A história da nossa já está em nosso site. Confere aí August 10, 2018
The 25-year-old forward doubled the lead with 19 minutes remaining after unleashing a low shot beyond Silva.
Hosts Atletico Tucuman were too good for Atletico Nacional, claiming a 2-0 win in Argentina.
Leandro Diaz and Guillermo Acosta were on target to see off the Colombian visitors.
Meanwhile, 10-man River Plate held Racing Club to a goalless draw in their all-Argentinian affair.
