Diego Fabbrini and Kike were influential as Middlesbrough beat Bolton Wanderers in the Championship, while Carlisle United and Cambridge United played out an eight-goal thriller in League Two.
Aitor Karanka's Middlesbrough, losing play-off finalists last season, picked up their first league win of the campaign at the Riverside Stadium in a 3-0 triumph that saw David Nugent make his debut.
All of their goals came in the first half, with Fabbrini opening the scoring with a fierce 25-yard effort before twice setting up Kike.
Brighton and Hove Albion made it two wins from two as Tomer Hemed's 90th-minute penalty secured a 2-1 success at Fulham.
Relegated QPR remain winless after surrendering a two-goal lead to draw 2-2 against Cardiff City at Loftus Road, while Ipswich Town came from behind to see off Sheffield Wednesday 2-1, and Nottingham Forest matched that feat against Rotherham United.
Bristol City were left to rue a Luke Freeman red card as they let a 2-1 lead slip in a 4-2 defeat at home to Brentford, while Preston North End won 1-0 at fellow league newcomers Milton Keynes Dons despite playing the last seven minutes with 10 men.
In League One, Coventry City impressed again as Newcastle United loanee Adam Armstrong scored twice in a 4-0 rout of Millwall.
Rochdale sit just behind Tony Mowbray's men after winning 2-0 at Blackpool, while Sheffield United rebounded from their opening day 4-0 loss at Gillingham to beat Chesterfield 2-0.
