Anchored to the bottom of the standings for a majority of the season, Gladbach have climbed up to the relegation playoff position since Swiss coach Lucien Favre reversed the club's fortunes after taking over from Michael Frontzeck in February.
Currently sitting in 16th place on 35 points on the back of three wins in a row, including a victory over new champions Borussia Dortmund, Gladbach lead 17th-placed Eintracht Frankfurt by one point with bottom side St Pauli already relegated on 29.
"We simply need to win our last game and everything will be good," said club top scorer Marco Reus, who has netted 10 times and is in contention for a call-up to the German national side.
"The fact that we are in the play-off spot is extremely valuable. We now want to win the last game and I am 100 percent certain we will stay up," the 21-year-old told reporters.
"We must get all three points at Hamburg and this has been the case for every game since I arrived here," the former Hertha Berlin coach added.
"We are aware of the reality and there is no reason for euphoria. We want to win but if we lose and Frankfurt get a point at Borussia Dortmund then we are dead."
Getting a draw or even winning at Dortmund, who will look to crown their title triumph with a victory in front of more than 80,000 home fans, is a daunting task for Christoph Daum's frustrated team.
