Back-to-back Championship defeats have left Derby eight points behind second-placed Burnley and, with QPR only a point behind in fourth, Steve McClaren's side needs to return to winning ways quickly.
Dougie Freedman's men stand in Derby's way and Wanderers are on a high after three wins on the trot, the last of which was a 5-1 victory over Leeds United at Elland Road on Saturday.
QPR travel to Brighton and Hove Albion after ending a run of five games without a win against Birmingham City at the weekend.
The top two both have away trips to contend with as Burnley, fresh from a first win over rivals Blackburn Rovers in 35 years, face Birmingham at St Andrew's, while leaders Leicester City head to struggling Barnsley.
A morale-boosting 1-0 win against Nottingham Forest lifted Barnsley's hopes of pulling clear of the relegation zone, while Leicester have a five-point cushion at the summit.
Reading's place in the top six is under pressure from Wigan Athletic, who sprung another shock on Manchester City to progress to the FA Cup semi-finals on Sunday, while Forest are also in danger of dropping out of the play-places after three consecutive defeats.
Forest visit Aitor Karanka's Middlesbrough, while Wigan host Sheffield Wednesday.
Yeovil Town, unbeaten in five, host Ipswich Town as they hope to climb out of the bottom three for the first time since late September, and Paul Dickov's Doncaster Rovers welcome Watford to the Keepmoat Stadium.
