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Atletico Mineiro secured top spot in their Copa Libertadores group, while Emelec moved a step closer to the knockout round.
Ecuador international Juan Cazares scored twice as Mineiro routed Godoy Cruz 4-1 in Belo Horizonte on Tuesday.
And Mineiro pipped their Argentinean visitors to the summit thanks to Cazares' first-half double, while former Brazil internationals Elias and Fred were on target at Estadio Raimundo Sampaio.
And Brayan Angulo's first-half brace saw visitors Emelec move a point clear of third-placed Medellin with a game remaining.
It is still all to play for in Group 7 after leaders Nacional were held to a goalless draw by Zulia.
