Paraguay coach Ramon Diaz feels James Rodriguez's absence would be a significant blow to Colombia at the Copa America Centenario.
James is battling a shoulder injury suffered in the opening game of the tournament, but will be given until the last minute to prove his fitness for Tuesday's clash.
"It would be very significant," he told a news conference.
"He's one of the best players in the world. He has class and great football and human quality.
"It is a significant loss, but Colombia has other good players at good levels and have options to replace him."
"We have to be very smart. They had an extra day of recovery and didn't have to travel," Diaz said.
"These are things that must be taken into account because we made a huge effort against Costa Rica."
