Fabregas, who left the Arsenal stadium on crutches following a 2-2 draw, said he would undergo a scan on Thursday to ascertain the extent of the injury.
"I'm not good. I fear the worst, which is that I have broken something," Fabregas told reporters.
"We have to wait until tomorrow but I hope I can play in an Arsenal shirt again this season.
"I fear it won't be good news but I still hope it will be."
"He pulled his calf muscle and I think it's the end of the season for him," Arsenal manager Wenger told French TV channel Canal Plus.
"I do not include the World Cup. I think he will be ready for the World Cup," added Wenger, speaking of the tournament to be held in South Africa from June 11-July 11.
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