Mexico, preparing for next weekend's start to the third phase of Concacaf World Cup qualifiers, made it three wins out of three in warm-up matches in the United States having also beaten Wales and Bosnia.
The defeat was Brazil's first in 11 matches after they won their two previous friendlies on tour against Denmark and the U.S.
"Chicharito" Hernandez increased their lead with a penalty just past the half-hour after Juan brought down Dos Santos.
Brazil, whose striker Leandro Damiao had a early goal disallowed in a controversial offside decision, had the lion's share of possession but Mexico the better finishing.
"It was a good victory and now comes the best which is the qualifiers," Mexico midfielder Andres Guardado told broadcasters Televisa.
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