AC Milan forward Marco Borriello is set to miss Saturday's trip to Livorno and Tuesday's Champions League match at Marseille because of a back problem that will force him to train separately from his team mates for several days.
Dutchman Klaas-Jan Huntelaar is favourite to take his place up front alongside Alexandre Pato this weekend, when coach Leonardo will be looking for a strong response after slumping 4-0 to city rivals Inter Milan last time out.
Midfield enforcer Gennaro Gattuso has an ankle injury but is suspended anyway after being sent off in the derby defeat that left Milan on three points from two games.
Captain Alessandro Del Piero will miss out again on Saturday when Juventus seek continue their perfect start at Lazio.
The club said the forward, yet to have any league action this term, aims to be fit for Tuesday's Champions League game against Girondins Bordeaux after back and thigh problems.
Zdenek Grygera is unavailable too but full-back Fabio Grosso is poised to make his debut for Juve, after marking his return from a stint with Olympic Lyon by scoring the opening goal in Italy's 2-0 win over Bulgaria on Wednesday.
David Trezeguet should partner Amauri in attack if coach Ciro Ferrara rests Vincenzo Iaquinta, who was also on the scoresheet against Bulgaria and played in Saturday's 2-0 win in Georgia.
With in-form Argentine Mauro Zarate and captain Tommaso Rocchi both injury doubts, Lazio coach Davide Ballardini is likely to pair Pasquale Foggia and Julio Cruz in attack.
Lazio also won their opening two games and share the top spot with Juve, Genoa and Sampdoria.
Jose Mourinho may rotate his squad in Inter's home game against Parma on Sunday ahead of Wednesday's Champions League clash with Barcelona.
Midfielders Patrick Vieira and Sulley Muntari, and striker Mario Balotelli are tipped to come into the starting line with Wesley Sneijder and Diego Milito possibly in for a rest after duty with the Dutch and Argentine national teams. Champions Inter and promoted Parma both have four points.
Claudio Ranieri will be without Brazil goalkeeper Doni and full back Cicinho, both out with long-term injuries, in his maiden match in charge of Roma at Siena on Sunday when his side will be looking for their first points of the season.
