Remi Garde's men made a poor start to the season, with a failure to qualify from the UEFA Champions League's play-off stage compounded by shocking Ligue 1 form.
After winning their opening two league fixtures, Lyon then won just one of their next nine to heap the pressure on Garde.
But they have rebounded strongly, with Alexandre Lacazette crucial in his side's form revival as the young striker has contributed 18 goals in all competitions this term.
Unbeaten in all eight of their Europa League matches this season, Lyon finished on top of Group I before edging Chornomorets 1-0 on aggregate in the competition's last 32.
"We recovered well (from our slow start to the season)," he told RMC.
"It is wonderful now to have these three objectives (Lyon are also in the Coupe de la Ligue final where they will play PSG). Caution should be exercised for the Europa League.
"There are still beautiful teams in the race. (Plzen are) a worthy opponent.
"In my mind, the Europa League is an important goal. We play to qualify. I (will) think (about) putting my best team (out)."
Sparta Prague beat them 1-0 in the capital to extend their lead at the top of the league to eight points.
