Estudiantes and their hopes of reaching the Copa Libertadores last 16 were dashed by Botafogo despite beating Barcelona.
Juan Sebastian Veron's Estudiantes needed a win from their penultimate match on Thursday and they achieved that – accounting for Barcelona 3-0.
And Juan Cavallaro kept the Argentine team's slim chances alive with his 29th-minute strike – the forward side-footing from inside the penalty area.
Facundo Sanchez stole the show in the second half, netting twice as former Manchester United and Chelsea midfielder Veron – now Estudiantes president – came off the bench to help complete the scoring.
Rodrigo Pimpao's goal six minutes into the second half lifted Botafogo past visiting Nacional.
Meanwhile, Group 3 leaders River Plate – already assured of a last-16 berth – overcame Melgar 3-2.
