Four of Cardiff's five Premier League wins this season have come at home, with a 2-1 victory at bottom club Fulham in September marking the Welsh side's only away success.
Ole Gunnar Solskjaer's men are just two points ahead of Fulham, but have a good opportunity to pull away from the relegation zone with four of the final six games at the Cardiff City Stadium coming against sides in the bottom half of the table.
The first of those encounters is against Steve Bruce's Hull, who won away from home in the league for only the second time this term with a 2-0 triumph at Sunderland earlier this month.
A win for Cardiff could move Solskjaer's men out of the relegation places. However, the hosts will need to overcome the absence of a number of first-team players if they are to achieve that feat.
A 1-0 defeat to Southampton in their last outing left Bruce's men only three points above the drop zone and the former Sunderland and Wigan Athletic boss is well aware of the importance of Saturday's game.
"Every game is a big one in the Premier League and obviously this one has added significance," Bruce told the club's official website.
"If you can beat one of your rivals down the bottom it's a huge result for you. Just like (the win against) Sunderland did, it gives us that little bit of breathing space, which we all require."
The two sides drew 1-1 when they clashed at the KC Stadium earlier this season, Curtis Davies and Peter Whittingham the players on target.
