Manuel Pellegrini’s side have scored 12 goals in their last two games against Norwich and CSKA Moscow, meaning Sunderland - who sit second-bottom in the Premier League - are likely to have their work cut out as they go in search of just their second win of the season.
City will be full of confidence having qualified for the last 16 of the UEFA Champions League for the first time with a 5-2 beating of CSKA in midweek - a result that followed up a 7-0 hammering of Norwich last Saturday.
Pellegrini's men will also need to improve their poor recent record at Sunderland. The 2011-12 champions have lost 1-0 on each of their last three top-flight trips to the Stadium of Light.
Aguero was named Premier League player of the month on Friday, after scoring nine goals in his last six games in all competitions.
Negredo, meanwhile, scored a hat-trick in the victory over CSKA, meaning he has five goals in his last three matches.
Negredo’s Spain international team-mate David Silva will play no part against Sunderland, though, after he was ruled out for up to a month with a calf injury sustained against CSKA.
Second-bottom Sunderland failed to build on their 2-1 victory over arch-rivals Newcastle in Gus Poyet’s first home match in charge when they were beaten at Hull City last weekend.
A League Cup victory over Southampton in midweek was a tonic for Poyet’s charges, but they need to start picking up points in the league if they are to avoid a relegation scrap.
Striker Steven Fletcher is set to return to the starting line-up, but defender Andrea Dossena and midfielder Lee Cattermole are suspended after being sent off at Hull.
