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Hazard lasted just 18 minutes against Paris Saint-Germain at Stamford Bridge, with the Belgian star replaced by Andre Schurrle on a night that saw Chelsea defeat the French champions 2-0 to advance to the semi-finals on away goals.
Post-game, Chelsea manager Jose Mourinho confirmed the 23-year-old had picked up a calf injury and would miss at least two weeks.
"I had already felt some pain in my calf during the warming-up," said the PSG target, who was greeted by coach Laurent Blanc following his substitution.
"I didn't want to take a risk."
The injury puts him doubt for Premier League fixtures against Swansea and Sunderland as second-placed Chelsea seek to overhaul Liverpool's two-point lead atop of the table with five games remaining.
Hazard has been a standout performer Mourinho's men, scoring 14 goals in 33 league appearances this season.
