Having not been tested by Panama in midweek, Brazil were at full-strength for the clash against Ljubinko Drulovic's side.
They were restrained for large spells, however, and coach Luiz Felipe Scolari will be aware improvement is required despite Fred's well-taken winner.
Brazil's victory may do little to fill an expectant nation with great confidence. However, with Neymar getting almost 80 minutes of action on his road to full fitness and Fred scoring his first in Brazil colours since the Confederations Cup, there are reasons for the hosts to be optimistic.
After a lively opening from both sides, Aleksandar Kolarov threatened first when he struck an effort wide of Julio Cesar's left-hand post after nine minutes.
A combination of tenacious and robust defending helped keep Brazil's forwards well shackled, although Fred was next to threaten - his dipping strike veering off target 24 minutes in.
David Luiz was forced into a hurried clearance following Kolarov's fierce delivery before Aleksandar Mitrovic wasted the best chance of the half, heading wide with the goal at his mercy.
Indeed, Dusan Tadic perhaps could have opened the scoring for Serbia had he gambled on reaching a cross lofted into the hosts' box.
Fred subsequently ensured first blood went to Brazil - cleverly chesting Thiago's delivery to take Ivanovic out of the game before prodding home the opener.
There were to be no more goals, although Serbia's Milos Jojic and Brazil forward Jo hit the woodwork in the closing stages.
