Wolves will make mathematically sure of their ascent to the Championship with four games to spare if they better the result of third-placed Rotherham, who host mid-table Bradford City on Friday.
Wolves will expect to keep their part of the bargain at fourth-bottom Crewe Alexandra in one of 10 fixtures on Saturday.
Kenny Jackett's side have taken 13 points from a possible last 15 and kept six clean sheets in their last eight away matches, while Crewe are winless in five home games.
Carlisle, having collected only four points from their last 10 away assignments, must contend with their former striker Joe Garner, whose 18 goals have put him three short of League One’s leading marksman Britt Assombalonga.
Assombalonga, 21, will bid to help Peterborough United consolidate the final play-off spot against visiting Coventry City, who are spearheaded by his nearest rival on the scoring chart – and League One’s player of the month for March – Callum Wilson.
"We only have three players available from the last time we played Crawley on Boxing Day," rued manager Karl Robinson.
MK Dons have not scored in their last five home games – the last four of which were defeats – while Crawley have lost their last six outings to drop three points above the relegation zone.
