While Nigel Clough's men reached the last four of the League Cup on Tuesday with a 1-0 victory over Southampton, Yeovil secured an FA Cup third-round meeting versus Manchester United courtesy of a 2-0 triumph against Accrington Stanley.
The clubs have very different objectives in the third tier, though, with United - who reached the FA Cup semi-finals last season - chasing promotion and Gary Johnson's side looking to avoid the drop.
Dean Smith's charges, meanwhile, are unbeaten in six and sit just six points behind United.
Yeovil were sent into dreamland at Huish Park courtesy of two late goals against a plucky Stanley outfit, earning them the reward of a televised third-round clash against Louis van Gaal's top-flight giants next month.
Mark Cooper's side have won their last five league matches – conceding just one goal – to move within a point of the summit after 20 matches.
City will expect to hold onto their lead, though, as they travel to bottom club Crewe Alexandra.
The hosts have failed to win any of their last six games, and find themselves six points from safety going into Saturday's match.
Karl Robinson's men host eighth-placed Oldham Athletic, while Preston North End visit Peterborough United and Rochdale face Notts County – with both sides locked on 30 points.
Meanwhile, strugglers Leyton Orient travel to Barnsley, and Crawley Town meet Port Vale.
