The pair occupy third and second respectively, with Shrewsbury two points behind leaders Burton Albion, while Wycombe are a point further adrift.
The victors would climb to the summit if Burton were to slip up at home to Accrington Stanley.
With the likes of Southend United, Luton Town and Bury from the chasing pack all dropping points, Shrewsbury defender Cameron Gayle remains positive heading into Saturday's meeting at Adams Park.
"The boys tend to check the results after the game," he told the club's official website. "We don't tend to worry too much about what's happening in other games when our match is happening.
"We just concentrate on ourselves and go game by game. Apart from Burton winning, the other results went well for us.
"We're two points behind Burton and if we can get a win at Wycombe it puts us in a good position."
At the bottom, Hartlepool United visit Morecambe, Tranmere Rovers go to Northampton Town, while York City and Carlisle United go head to head in a crucial showdown at Bootham Crescent.
