"Our results in November have been catastrophic. There is a lot of disappointment and frustration in our dressing room. We must exceed ourselves," Lloris told reporters on Tuesday.
Second-placed Lyon have drawn their last three league games - at home to Olympique Marseille and Stade Rennes and at bottom club Grenoble - and failed to secure top spot in their Champions League group when they lost 1-0 at Fiorentina last week.
Olympique Marseille, seventh in the standings on 22 points, travel to neighbouring Nice with their thoughts already on next week's clash with Real Madrid in the Champions league, in which the French team have a chance of qualifying to the knockout stage.
"We have got to dream and hope but we must first concentrate on Saturday's game," coach Didier Deschamps told the club's website.
"The match against Madrid will be a gala game but the championship is our first priority and we can't afford defeats anymore," he added.
