"He (Mido) was excluded due to a tactical point of view," Shawki Gharib, Egypt's assistant coach, told Reuters.
Mido, on loan from English Premier League rivals Middlesbrough, had been left out of the squad named on Thursday despite a dearth of attacking options.
Egypt will also be without forward Emad Meteb, sidelined due to knee injury.
Mido, a former Tottenham Hotspur striker who has scored two goals for Wigan since joining in January, will miss World Cup qualifiers against Algeria on June 7 and Rwanda on July 5.
Squad:
Goalkeepers: Essam Al Hadari (Sion), Abdul Wahed Al Sayed (Zamalek), Mohamed Sobhi (Ismaili), Al Hani Soliman (Itiihad Alexandria).
Defenders: Hani Said (Zamalek), Mahmoud Fathallah (Zamalek), Wael Gomaa (Al Ahli), Sherif Abdul Fadhil (Ismaili), Ahmed Said (Haras Hodoud), Ahmed Al Muhammadi (ENPPI), Sayed Moawad (Al Ahli), Hazem Emam (Zamalek), Ahmed Samir Farag (Ismaili).
Midfielders: Ahmed Fathi (Al Ahli), Mohamed Shawki (Middlesbrough), Hosni Abd Rabu (Al Ahli Dubai), Ahmed Khairy (Ismaili), Mohamed Soliman (Ismaili), Abdul Aziz Tawfiq (ENPPI), Ahmed Hassan (Al Ahli), Mohamed Aboutrika (Al Ahli).
Forwards: Ahmed Eid (Haras Hodoud), Mohamed Zidan (Boroussia Dortmund), Mohamed Abougreisha (Ismaili), Ahmed Abdul Ghani (Haras Hodoud), Ahmed Raouf (ENPPI), Ehab Al Masri (Arab Contractors), Amr Zaki (Wigan Athletic).
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