Luqueno's 2-1 road win over General Diaz on Saturday was followed by Cerro Porteno's inability to convert a lead into three points, as they were held 1-1 by Olimpia.
Cerro's slip up saw Libertad move three points clear at the top, after a 4-1 thrashing of Guarani.
Luis Mino's penalty and Rodrigo Teixeira's goal prior to half-time built Luqueno a commanding 2-0 lead at the interval at the Estadio General Adrian Jara in Luque.
Cerro Porteno fell four points behind Libertad, after Christian Ovelar's second-half goal cancelled out Jose Ortigoza's effort on the stroke of half-time.
To put Libertad's goals into perspective, they had scored 20 in 13 games before exploding to life of late.
Ismael Benegas and Nestor Camacho struck inside the first 35 minutes, before Gustavo Mencia added Libertad's third on the hour-mark.
Nacional Asuncion needed only Julian Benitez's seventh-minute goal to deal 12 de Octubre a 1-0 defeat - the strugglers' fourth straight loss.
Sol railed 2-0 after 16 minutes - having conceded a first-minute own goal - but were level at the break thanks to Claudio Correa's double.
And Aureliano Torres converted a penalty at the death to make it two wins in Sol's past three, and five games unbeaten.
