Pep Guardiola's side have swept all before them winning 12 of their last 13 matches to go eight points clear at the top of the standings, and fourth-placed Villarreal have the last chance to trip them up before the winter break.
Barca's run has seen them demolish second-placed Valencia 4-0, third-placed Sevilla 3-0, and fifth-placed Atletico Madrid 6-1. Last weekend, champions Real Madrid succumbed 2-0 to slip down to sixth.
"Barca are the best team in the league by a long way but they are not invincible," Villarreal's French midfielder said.
"We have done well against Barca in recent meetings and beaten them a few times. It suits us that they play a similar style of football."
The weekend's other outstanding encounter sees struggling Real Madrid host Valencia on Saturday.
"As a footballer you feel the need for revenge because of the way we lost that game (the second leg)," Valencia winger Joaquin said earlier in the week.
"It's clear Real Madrid are not in good shape but we cannot fall into the trap of thinking it will be easy to beat them."
Real's new coach Juande Ramos lost his first league game in charge at the Nou Camp last weekend, but was pleased with the spirited way in which they thwarted Barca for long periods.
