The Germany international - plagued by ankle problems in 2014 - was forced off midway through the first half of Tuesday's DFB-Pokal victory at Dynamo Dresden after colliding with Dennis Erdmann.
While it sparked fears over Reus potentially facing another lengthy layoff, coach Jurgen Klopp initially explained the injury was "only a dead leg".
A subsequent statement confirmed Reus had only sustained bruising "above the knee" but, with the problem now affecting a wider area, his involvement in this weekend's Bundesliga fixture is uncertain.
"Reus' bruise is currently spread over the entire thigh," Klopp told a news conference on Thursday.
"Aubameyang will train tomorrow," he added. "With Sahin it seems unlikely, but you never know."
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